> The company says that the drug was generally well tolerated, but that’s on the oncology scale.
> ...
> He’s been on daraxonrasib since early this year, and describes it this way: “. . .it’s a nasty drug. It causes crazy stuff like my body can’t grow skin and so I bleed all out of a whole bunch of parts of me that shouldn’t be bleeding” If you go to that link above, be prepared, because he also looks like he’s had aqua regia thrown all over him (and apparently feels a bit like that, too). But his tumor volume has gone down by about 75%, and there’s a very strong chance that he wouldn’t still be alive at all without having gone on the drug.
rvnx 1 hours ago [-]
The founders of Lovable and Builder.ai individually received more funds than the whole group of the researchers behind this medicine...
Retric 26 minutes ago [-]
That’s like talking about the ROI of a winning lottery ticket.
We can’t know ahead of time which medicine works so you need to fund many teams at the beginning.
modzu 4 minutes ago [-]
"survival" is the wrong word; its terminal. honestly the drugs and chemo and treatments they put pancreatic patients through for possibly a few more (not very nice) weeks is almost criminal. a good doctor will tell you to go make the most of those 3 months post diagnosis. that said its nice to see progress against one of the worst cancers out there and i hope it leads to genuine breakthroughs. but this drug is nothing anybody wants, even if they think they do
Totally naive question: is this a situation where stacking the drug with chemo might be even better?
1 minutes ago [-]
chilldsgn 1 hours ago [-]
I hope they can get this to people quickly. Someone I love has been diagnosed with stage 3 end of Feb this year and it's utter hell. For everyone, not just the patient.
thowland 1 hours ago [-]
While not fully approved, the company has early access available to people who meet the treatment criteria and would potentially benefit. Their HCP should evaluate this (it's not all types of pancreatic cancer, and it's not a silver bullet - but it looks like its double the survival time than current chemo). Hopefully this evolves into a new class of treatment.
Paywalled but has a free access option if you make an account.
shevy-java 36 minutes ago [-]
Always a money-generator.
Researchers need to find permanent cures.
hackyhacky 29 minutes ago [-]
Always baffling to me that people accuse researchers and doctors, people who have devoted their life to helping others, of brazen greed and deception. With no evidence, of course. Maybe the accusation says more about you than about them?
> ...
> He’s been on daraxonrasib since early this year, and describes it this way: “. . .it’s a nasty drug. It causes crazy stuff like my body can’t grow skin and so I bleed all out of a whole bunch of parts of me that shouldn’t be bleeding” If you go to that link above, be prepared, because he also looks like he’s had aqua regia thrown all over him (and apparently feels a bit like that, too). But his tumor volume has gone down by about 75%, and there’s a very strong chance that he wouldn’t still be alive at all without having gone on the drug.
We can’t know ahead of time which medicine works so you need to fund many teams at the beginning.
https://www.nejm.org/doi/full/10.1056/NEJMoa2505783
Paywalled but has a free access option if you make an account.
Researchers need to find permanent cures.